尿液碱化对阳离子白蛋白所致肾脏改变的影响。

Effect of urinary alkalinization on renal changes produced by cationic albumin.

作者信息

Coimbra T M, DeGiacobbi G, Gouveia M A, Lachat J J, De Carvalho I F

出版信息

Nephron. 1984;38(4):261-6. doi: 10.1159/000183320.

Abstract

40-mg doses of human cationic (CA) or anionic (AA) albumin were administered intravenously to 48 normal female rats. Sodium bicarbonate (NaHCO3) was administered to 8 of these animals before CA or AA. Urine alkalinization caused increased renal CA excretion in CA-injected animals, which also showed marked reduction of the intensity of the renal changes produced by CA.

摘要

将40毫克剂量的人阳离子（CA）或阴离子（AA）白蛋白静脉注射给48只正常雌性大鼠。在注射CA或AA之前，给其中8只动物注射碳酸氢钠（NaHCO₃）。尿液碱化导致注射CA的动物肾脏CA排泄增加，这些动物肾脏由CA引起的变化强度也显著降低。