Pinessi L, Bianco C, Cavallo G, Bergamasco B
Minerva Med. 1984 Nov 3;75(42):2533-7.
Although the literature recognises the involvement of neuropeptide structures in the genesis of epilepsy, only tentative preliminary data are available at present. Experiments indicate that neuropeptides primarily involved in the genesis of epilepsy are leuencephalin, metencephalin and beta-endorphin. Their convulsion properties are apparently related to the specific levels, locations and convulsive potential of the individual substances. A qualitative and/or quantitative change to the GABA-neuropeptide balance may also be involved in convulsive disorders; decreased GABA fluid levels have been identified in both severely epileptic patients and infants with febrile convulsions. Neuropeptide modulation and GABAergic neurotransmission clearly therefore play a major role in the regulation of cortical bioelectrical activity. It is therefore likely that their interaction is involved in the genesis of epilepsy.
虽然文献认可神经肽结构参与癫痫的发生，但目前仅有初步的试探性数据。实验表明，主要参与癫痫发生的神经肽是亮脑啡肽、甲硫脑啡肽和β-内啡肽。它们的惊厥特性显然与各物质的特定水平、位置和惊厥潜力有关。GABA-神经肽平衡的定性和/或定量变化也可能与惊厥性疾病有关；在重度癫痫患者和热性惊厥婴儿中均已发现GABA液水平降低。因此，神经肽调节和GABA能神经传递显然在皮层生物电活动的调节中起主要作用。所以，它们之间的相互作用很可能参与了癫痫的发生。
