Rainer H
Onkologie. 1984 Oct;7(5):276-84. doi: 10.1159/000215461.
Many cytotoxic agents exhibit response in oat cell lung cancer. According to response rates those substances my be divided into 3 subgroups. Combination of chemotherapeutic drugs is considerable more active as compared to single agent therapy. Actuarial survival was significantly improved by chemotherapy and is related to dosages and the absolute number of cytotoxics used. Sequential chemotherapy with sequential administration of non-cross resistant schemes seems to be the optimal therapeutic strategy at present time. A ten-fold increase of survival has been shown including a small percentage of long term survivors. It seems likely to assume that those therapies combined in an optimal manner without dose-reductions during induction therapy will further improve survival and percentage of long term survivors.
许多细胞毒性药物对燕麦细胞肺癌有反应。根据反应率，这些物质可分为3个亚组。与单药治疗相比，化疗药物联合使用的活性明显更高。化疗显著提高了精算生存率，且与所用细胞毒性药物的剂量和绝对数量有关。采用非交叉耐药方案序贯给药的序贯化疗似乎是目前最佳的治疗策略。生存率提高了10倍，包括一小部分长期存活者。似乎可以假定，那些在诱导治疗期间以最佳方式联合使用且不减量的治疗方法将进一步提高生存率和长期存活者的比例。
