Quock R M, Bloom A S, Sadowski J A
Pharmacol Biochem Behav. 1984 Nov;21(5):733-6. doi: 10.1016/s0091-3057(84)80011-8.
Apomorphine-induced stereotypic climbing behavior in mice was significantly potentiated by pretreatment with the opiate receptor blocker naloxone. In animals additionally pretreated with alpha-methyl-p-tyrosine, brain levels of norepinephrine (NE) and dopamine (DA) were markedly reduced and naloxone potentiation of apomorphine-induced stereotypic climbing was blocked. In mice pretreated with diethyldithiocarbamic acid, brain NE was slightly reduced, brain DA was slightly elevated but naloxone potentiation of apomorphine-induced stereotypic climbing was unaltered. In animals pretreated with reserpine, both brain NE and DA were significantly reduced by naloxone potentiation of apomorphine-induced stereotypic climbing was not affected. In other experiments, pretreatment with low doses of the alpha-adrenergic receptor blocker BE-2254 failed to suppress climbing activity induced by apomorphine alone but did successfully prevent naloxone potentiation of apomorphine-induced stereotypic climbing. These findings suggest the possibility that NE and alpha-adrenergic receptors might play a role in the potentiating influence of naloxone upon apomorphine-induced stereotypic climbing activity in mice.
阿扑吗啡诱导的小鼠刻板攀爬行为在经阿片受体阻滞剂纳洛酮预处理后显著增强。在额外经α-甲基-对-酪氨酸预处理的动物中，去甲肾上腺素（NE）和多巴胺（DA）的脑内水平显著降低，且纳洛酮对阿扑吗啡诱导的刻板攀爬的增强作用被阻断。在用二乙基二硫代氨基甲酸预处理的小鼠中，脑内NE略有降低，脑内DA略有升高，但纳洛酮对阿扑吗啡诱导的刻板攀爬的增强作用未改变。在用利血平预处理的动物中，脑内NE和DA均显著降低，纳洛酮对阿扑吗啡诱导的刻板攀爬的增强作用未受影响。在其他实验中，用低剂量的α-肾上腺素能受体阻滞剂BE-2254预处理未能抑制单独阿扑吗啡诱导的攀爬活动，但成功地阻止了纳洛酮对阿扑吗啡诱导的刻板攀爬的增强作用。这些发现提示NE和α-肾上腺素能受体可能在纳洛酮对阿扑吗啡诱导的小鼠刻板攀爬活动的增强影响中发挥作用。
