Croucher M J, Meldrum B S, Jones A W, Watkins J C
Brain Res. 1984 Nov 19;322(1):111-4. doi: 10.1016/0006-8993(84)91186-7.
The effect of gamma-D-glutamylaminomethylsulphonic acid (GAMS) on sound-induced seizures has been assessed in DBA/2 mice. All phases of the seizure response are suppressed following intracerebroventricular injection (ED50 values: 0.077 mumol for tonic seizure, 0.132 mumol for wild running) or intraperitoneal injection (ED50: 1.21 mmol/kg for tonic seizure, 4.95 mmol/kg for wild running). The results are discussed in relation to the involvement of 'kainate' and 'quisqualate' receptors in the generation and propagation of seizures.
已在DBA/2小鼠中评估了γ-D-谷氨酰胺甲基磺酸（GAMS）对声音诱发癫痫发作的影响。脑室内注射（ED50值：强直性发作0.077 μmol，狂奔0.132 μmol）或腹腔注射（ED50：强直性发作1.21 mmol/kg，狂奔4.95 mmol/kg）后，癫痫发作反应的各个阶段均受到抑制。结合“红藻氨酸盐”和“quisqualate”受体在癫痫发作的产生和传播中的作用对结果进行了讨论。
