Scoggins B A, Coghlan J P, Denton D A, Fei D W, Nelson M A, Tregear G W, Tresham J, Wang X M
Clin Exp Pharmacol Physiol. 1984 Jul-Aug;11(4):365-7. doi: 10.1111/j.1440-1681.1984.tb00280.x.
Infusion of synthetic ovine CRF (10 or 100 micrograms/h) into the lateral lateral cerebral ventricle for 24 h increased mean arterial blood pressure of conscious sheep. CRF infusion also increased urine output and sodium excretion. Intravenous infusion of CRF (100 micrograms/h) or intraventricular infusion of artificial CSF had no effect on blood pressure. Intraventricular infusion of ACTH (1-24) at 0.5 micrograms/kg per day, a rate of infusion which has no systemic effect on blood pressure, also raised mean arterial pressure. These studies suggest that two peptides involved in the physiological response to 'stress' may influence blood pressure by mechanisms which do not involve stimulation of adrenocortical steroid production.
向清醒绵羊的侧脑室输注合成羊促肾上腺皮质激素释放因子（CRF）（10或100微克/小时）24小时可升高其平均动脉血压。输注CRF还可增加尿量和钠排泄。静脉输注CRF（100微克/小时）或脑室内输注人工脑脊液对血压无影响。以每天0.5微克/千克的速率脑室内输注促肾上腺皮质激素（ACTH）（1-24），该输注速率对血压无全身影响，但也可升高平均动脉压。这些研究表明，参与对“应激”生理反应的两种肽可能通过不涉及刺激肾上腺皮质类固醇生成的机制影响血压。
