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米兰吸毒者中出现伴有免疫异常的持续性、不明原因的全身性淋巴结病疫情。

Outbreak of persistent, unexplained, generalized lymphadenopathy with immunological abnormalities in drug addicts in Milan.

作者信息

Lazzarin A, Galli M, Introna M, Negri C, Mantovani A, Mella L, Ferrante P, Parravicini C, Trombini M, Aiuti F

出版信息

Infection. 1984 Nov-Dec;12(6):372-6. doi: 10.1007/BF01645217.

Abstract

Persistent unexplained lymphadenopathy (LAS) with intermittent fever, weight loss, night sweats and malaise was observed from March to October 1983 in 16 of 133 intravenous drug addicts who had been followed for at least two years in a Center for Drug Addicts Assistance in Milan, Italy. All the subjects lived in a restricted suburban area and indulged in frequent toxicomanic practices and mutual sexual intercourse. The subjects showed immunological alterations such as lymphopenia (50%), decreased T helper/T suppressor ratio (93%), both these abnormalities (43%), decreased T helper cells (75%), increased T suppressor cytotoxic cells (81%), decreased natural killer (NK) activity (77%), anergy (50%) or hypoergy (43%) to recall skin testing and elevated levels of IgG (87%). Anti-HTLV III antibodies were found in 14 of 16 (87%) patients with LAS and in 3 of 11 (27%) symptom-free drug addicts belonging to the same group. It will be important to assess in the future whether this clinical and immunological picture results in acquired immunodeficiency syndrome in an area so far untouched by this disease.

摘要

1983年3月至10月期间,在意大利米兰一家戒毒援助中心对133名静脉注射吸毒者进行了至少两年的跟踪观察,其中16人出现了持续不明原因的淋巴结病(LAS),伴有间歇性发热、体重减轻、盗汗和身体不适。所有这些受试者都生活在一个有限的郊区,频繁沉溺于吸毒行为并相互进行性行为。这些受试者表现出免疫改变,如淋巴细胞减少(50%)、辅助性T细胞/抑制性T细胞比例降低(93%)、这两种异常情况同时出现(43%)、辅助性T细胞减少(75%)、细胞毒性抑制性T细胞增加(81%)、自然杀伤(NK)活性降低(77%)、对回忆性皮肤试验出现无反应性(50%)或反应减弱(43%)以及IgG水平升高(87%)。在16例LAS患者中有14例(87%)以及在同一组11例无症状吸毒者中有3例(27%)检测到抗HTLV III抗体。未来评估这种临床和免疫状况是否会在一个迄今未受该疾病影响的地区导致获得性免疫缺陷综合征将很重要。

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