The use of collagenase-clostridiopeptidase combined with chloramphenicol in orthopaedics and traumatology.

The authors report a consecutive group of 95 patients suffering from chronic ulceration treated by a mixture of Collagenase Clostridiopeptidase A and 1% Chloramphenicol. Some cases involved skin only, some affected skin and muscle, and some also affected bone. The treatment was successful in all cases. The mixture acts by inducing debridement and cleansing of the necrotic areas and stimulating granulation tissue formation. This is followed by epithelialisation. At the same time the vitality of the deep tissues is maintained, even when it involves bone.