Groce D F, Kimbrough R D
J Toxicol Environ Health. 1984;14(5-6):695-706. doi: 10.1080/15287398409530618.
Firemaster FF-1, a polybrominated biphenyl (PBB) mixture, was dissolved in corn oil and given as a dose of 200 mg/kg body weight to Sherman rats on d 7 and 14 of pregnancy. Control rats received equivalent doses of corn oil alone. Selected pups and all dams were killed 1 mo after pups were weaned. A total of 50 male and 50 female offspring per group were followed until they were 2 yr old. The livers of offspring killed at the ages of 2 mo and 2 yr had PBB levels of 2,4 (SD 1.2) and 0.8 (SD 0.65) mg/kg for females and 3.0 (SD 1.6) and 0.6 (SD 0.37) mg/kg for males, respectively. The incidence of hepatocellular carcinomas was 3/51 (5.9%) and 4/41 (9.6%) after 2 yr in females and males, respectively. Hepatocellular carcinomas were not observed among the controls. Neoplastic (hyperplastic) nodules of the liver were present in 9/51 (17.6%) and 2/41 (4.9%) of exposed females and males, respectively, whereas only 2/48 (4.2%) of control females and no control males had neoplastic (hyperplastic) nodules. Body weights were lower in PBB-exposed rats at ages 1, 6, 12, and 24 mo. Survival rates from birth to weaning were lower in PBB-exposed pups (89%) than in controls (98%). Mortality was two times higher in PBB-exposed males (64%) than in control males (32%) after 2 yr. Transplacental PBB exposure and exposure through milk resulted in PBB body burdens in the offspring still measurable at the end of their lifespan. These offspring had increased mortality rates and lower body weights than controls, and they developed hepatocellular carcinomas.
多溴联苯混合物Firemaster FF - 1溶解于玉米油中，在妊娠第7天和第14天以200毫克/千克体重的剂量给予谢尔曼大鼠。对照大鼠仅接受等量的玉米油。断奶后1个月，处死部分选定的幼崽和所有母鼠。每组共50只雄性和50只雌性后代被跟踪至2岁。2个月龄和2岁时处死的后代肝脏中，雌性多溴联苯水平分别为2.4（标准差1.2）毫克/千克和0.8（标准差0.65）毫克/千克，雄性分别为3.0（标准差1.6）毫克/千克和0.6（标准差0.37）毫克/千克。2年后，雌性和雄性肝细胞癌的发生率分别为3/51（5.9%）和4/41（9.6%）。对照组未观察到肝细胞癌。暴露的雌性和雄性中，分别有9/51（17.6%）和2/41（4.9%）出现肝脏肿瘤性（增生性）结节，而对照雌性中只有2/48（4.2%）出现，对照雄性未出现。暴露于多溴联苯的大鼠在1、6、12和24月龄时体重较低。暴露于多溴联苯的幼崽从出生到断奶的存活率（89%）低于对照组（98%）。2年后，暴露于多溴联苯的雄性死亡率（64%）是对照雄性（32%）的两倍。经胎盘暴露于多溴联苯以及通过乳汁暴露导致后代体内的多溴联苯负荷在其寿命结束时仍可测量。这些后代的死亡率高于对照组，体重低于对照组，并且发生了肝细胞癌。
