Weissman B A, Skolnick P, Klein D C
Pharmacol Biochem Behav. 1984 Dec;21(6):821-4. doi: 10.1016/s0091-3057(84)80059-3.
The density of "peripheral-type" binding sites for benzodiazepines (PBS) in the rat pineal gland was reduced by approximately 50% three weeks after superior cervical ganglionectomy or exposure to constant light; the apparent affinity of [3H]Ro 5-4864 (the prototype ligand for these sites) remained unchanged. In contrast, neither the density of PBS nor the apparent affinity of [3H]Ro 5-4864 for these sites was altered in cerebral cortex by these procedures. The demonstration that PBS density is under neural control in the pineal gland suggests that these sites may have a physiologic role. The high density of PBS in pineal (approximately 24 pmol/mg protein) suggests that this tissue may be a useful model to study both the physiologic and pharmacologic function of these sites.
大鼠松果体中苯二氮䓬“外周型”结合位点（PBS）的密度，在颈上神经节切除术后三周或持续光照三周后降低了约50%；[3H]Ro 5-4864（这些位点的原型配体）的表观亲和力保持不变。相比之下，这些操作并未改变大脑皮层中PBS的密度以及[3H]Ro 5-4864对这些位点的表观亲和力。松果体中PBS密度受神经控制这一发现表明，这些位点可能具有生理作用。松果体中PBS的高密度（约24 pmol/mg蛋白质）表明，该组织可能是研究这些位点生理和药理功能的有用模型。
