雄激素对大鼠腹侧前列腺中聚腺苷酸聚合酶的调节作用。
Androgen regulation of poly(A) polymerase in the ventral prostate of rat.
作者信息
Raju V S, Reddy P R
出版信息
Steroids. 1984 Apr;43(4):407-14. doi: 10.1016/0039-128x(84)90015-1.
The effect of various hormones on the levels of poly(A) polymerase in the ventral prostate of castrated rats was investigated. It was observed that this enzyme is specifically induced by androgens; progesterone and estradiol-17 beta did not cause stimulation of poly(A) polymerase activity. Dihydrotestosterone-induced poly(A) polymerase was inhibited by cordycepin, actinomycin-D and cycloheximide, which indicates that the genetic transcription leading to the enzyme poly(A) polymerase is regulated by androgens in the ventral prostate.
研究了各种激素对去势大鼠腹侧前列腺中多聚腺苷酸聚合酶水平的影响。观察到这种酶是由雄激素特异性诱导的；孕酮和雌二醇-17β不会刺激多聚腺苷酸聚合酶的活性。双氢睾酮诱导的多聚腺苷酸聚合酶受到虫草素、放线菌素-D和环己酰亚胺的抑制，这表明导致多聚腺苷酸聚合酶的基因转录在腹侧前列腺中受雄激素调节。
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