[Conditioned posture changes in dogs after systemic administration of dopaminergic agents].

Influence of systemic injection of some dopaminergic drugs on conditioned postural rearrangement prior to instrumental movement realization and on other motor components of instrumental reaction as well as on the performance of the instrumental task itself--was studied in chronic experiments in 5 dogs on a model of instrumental defensive reflexes connected with maintenance of a certain posture. Drugs were used influencing the nigrostriate dopaminergic system, i.e. dopamine agonist L-DOPA and haloperidol blocking dopamine striate receptors. All the motor components of the instrumental reaction and first of all conditioned postural rearrangement were modified by systemic haloperidol injection. Initial components of the postural rearrangement were modified to the greatest extent, in particular the period of preparation of the animal to the posture change increased. On the contrary, the latency of initiation of postural rearrangement was sharply shortened by systemic injection of L-DOPA. On the other hand, the main component of the postural change, i.e. redistribution of body mass among the bearing limbs (the values of which significantly increased after preliminary stimulation of the head of the caudate nucleus) changed insignificantly during modulation of the striatum dopamine level.