Heffron J J, O'Callaghan A M, Duggan P F
Biochem Int. 1984 Nov;9(5):557-62.
The widely-used food dye Erythrosin B inhibited ATP-dependent Ca2+ accumulation by rat brain microsomes, half-maximal inhibition requiring 1 microM dye. Addition of 0.5-20 microM dye to microsomes preloaded with Ca2+ did not cause any net Ca2+ release. 10 microM dye produced a constant inhibition of Ca2+ accumulation as the intravesicular free Ca2+ was lowered suggesting that, at low concentrations, it acts on the uptake system only. Ca2+ accumulation was ten-fold more sensitive to the dye than Erythrosin B-induced neurotransmitter release reported by others. Higher dye concentrations (100 microM) caused Ca2+ release.
广泛使用的食用色素赤藓红B抑制大鼠脑微粒体中ATP依赖的Ca2+积累，半最大抑制浓度为1 microM染料。向预先加载Ca2+的微粒体中添加0.5 - 20 microM染料不会导致任何净Ca2+释放。当囊泡内游离Ca2+降低时，10 microM染料对Ca2+积累产生持续抑制，表明在低浓度下，它仅作用于摄取系统。Ca2+积累对该染料的敏感性比其他人报道的赤藓红B诱导的神经递质释放高十倍。更高浓度的染料（100 microM）会导致Ca2+释放。
