Nakazawa S, Sato H, Narita A, Nakazawa S, Suzuki H, Chikaoka H, Tazoe K
Jpn J Antibiot. 1984 Nov;37(11):2174-87.
Sulbactam/cefoperazone (SBT/CPZ) was evaluated in the treatment of pediatric patients to have the following results: Peak serum concentrations which occurred just after the drip infusion of 20 mg/kg SBT/CPZ were 36.4 micrograms/ml and 8.6 micrograms/ml for CPZ and SBT, respectively. The half-life of CPZ was 1.91 hours, and that of SBT, 0.97 hour. Following the 40 mg/kg drip infusion, the peak serum concentration of CPZ was 79.1 micrograms/ml, and that of SBT, 27.0 micrograms/ml. The half-lives were 1.99 hours for CPZ, and 1.07 hours for SBT, respectively. In 6 hours after drip infusion of 20 mg/kg and 40 mg/kg 21.7, 37.0% of CPZ and 41.6, 85.6% of SBT were excreted in urine. Daily doses of about 50-90 mg/kg SBT/CPZ were administered by intravenous or drip infusion to 26 pediatric patients with acute infections such as lacunar tonsillitis, bronchitis, bronchopneumonia, suppurative diseases caused by Staphylococcus (staphylococcal scalded skin syndrome), purulent parotitis, cervical lymphadenitis, phlegmon and acute UTI related with ABPC/CPZ resistant beta lactamase producing E. coli. SBT/CPZ demonstrated the bacteriological effect on all the causative organisms. The clinical efficacy was also confirmed with the efficacy rate of 88.5%. No side effects were observed in all the cases though transient eosinophilia developed in 2 patients.
对小儿患者使用舒巴坦/头孢哌酮（SBT/CPZ）进行治疗评估，结果如下：静脉滴注20mg/kg SBT/CPZ后即刻测得的血清峰值浓度，头孢哌酮（CPZ）为36.4μg/ml，舒巴坦（SBT）为8.6μg/ml。CPZ的半衰期为1.91小时，SBT的半衰期为0.97小时。静脉滴注40mg/kg后，CPZ的血清峰值浓度为79.1μg/ml，SBT为27.0μg/ml。CPZ的半衰期为1.99小时，SBT为1.07小时。静脉滴注20mg/kg和40mg/kg后6小时，分别有21.7%、37.0%的CPZ和41.6%、85.6%的SBT经尿液排出。对26例患有急性感染（如陷窝性扁桃体炎、支气管炎、支气管肺炎、由金黄色葡萄球菌引起的化脓性疾病（葡萄球菌性烫伤样皮肤综合征）、化脓性腮腺炎、颈部淋巴结炎、蜂窝织炎以及与耐ABPC/CPZ产β-内酰胺酶大肠杆菌相关的急性尿路感染）的小儿患者，通过静脉注射或静脉滴注给予每日约50 - 90mg/kg的SBT/CPZ。SBT/CPZ对所有致病微生物均显示出抗菌作用。临床疗效也得到证实，有效率为88.5%。所有病例均未观察到副作用，不过有2例患者出现了短暂性嗜酸性粒细胞增多。
