Hayashi I, Katsuda Y, Nomura Y, Tashiro H, Ookuma T
Gan No Rinsho. 1984 Dec;30(15):1924-30.
A 40 year-old female underwent mastectomy for a rapidly growing left breast mass. Histologically, the tumor was composed of invasive ductal carcinoma with squamous metaplasia, a cartilaginous component and a pleomorphic sarcoma-like component. In each histologic feature, gradual transition was recognized. A diagnosis of carcinoma with metaplasia (squamous and cartilaginous type) of the breast was made. The cartilaginous component in this case is probably the result of direct cartilaginous metaplasia of carcinoma cells and cartilaginous metaplasia followed upon carcinoma cells into small undifferentiated tumor cells and pleomorphic sarcomatous cells.
一名40岁女性因左乳迅速增大的肿块接受了乳房切除术。组织学检查显示，肿瘤由伴有鳞状化生的浸润性导管癌、软骨成分和多形性肉瘤样成分组成。在每个组织学特征中，均可见逐渐过渡。诊断为乳腺化生癌（鳞状和软骨型）。本例中的软骨成分可能是癌细胞直接软骨化生的结果，癌细胞先发生软骨化生，然后转变为小的未分化肿瘤细胞和多形性肉瘤细胞。
