Bern M M, Suzuki K, Mann K, Tracy P, Hoyer L, Jensen W, Gallivan M, Arkin C, Davis G
Thromb Res. 1984 Dec 15;36(6):485-95. doi: 10.1016/0049-3848(84)90188-9.
The role of Protein C in combined factor V/VIII deficiency was examined by reducing the Protein C concentration using warfarin therapy in a patient with the combined deficiency. The factor VIII deficiency was like Hemophilia-A, with deficiency of VIII:C and VIII:C(Ag), but normal VIIIR:Ag and VIIIR:cof. The factor V deficiency was due to loss of the V antigen. During warfarin therapy the Protein C level was reduced, but concentrations of factors V and VIII did not change. Protein C Inhibitor was normal throughout. Thus combined factor V/VIII deficiency is not related to Protein C levels.
通过对华法林治疗的联合因子V/VIII缺乏症患者降低蛋白C浓度，研究了蛋白C在联合因子V/VIII缺乏症中的作用。该因子VIII缺乏症类似血友病A，表现为VIII:C和VIII:C(Ag)缺乏，但VIIIR:Ag和VIIIR:cof正常。因子V缺乏是由于V抗原缺失所致。在华法林治疗期间，蛋白C水平降低，但因子V和VIII的浓度未发生变化。蛋白C抑制剂始终正常。因此，联合因子V/VIII缺乏症与蛋白C水平无关。
