瘦小鼠和遗传性肥胖（ob/ob）小鼠脂肪细胞膜腺苷酸环化酶活性的阿伦尼乌斯图特征
Arrhenius plot characteristics of adipocyte-plasma-membrane adenylate cyclase activity in lean and genetically obese (ob/ob) mice.
作者信息
French R R, York D A
出版信息
Biosci Rep. 1984 Dec;4(12):1001-8. doi: 10.1007/BF01116692.
Arrhenius plots of fluoride- and guanine-nucleotide-stimulated adenylate cyclase activity were linear in adipocyte plasma membranes from lean and obese (ob/ob) mice. Arrhenius plots of isoprenaline-stimulated adenylate cyclase activity in hepatic plasma membranes biphasic in both groups. The results were biphasic in membranes from lean mice but linear in membranes from obese mice. In contrast, Arrhenius plots of glucagon-stimulated adenylate cyclase activity in hepatic plasma membranes were biphasic in both groups. The results suggest that the coupling between the beta-receptor and the regulatory unit of adenylate cyclase, which has been observed to be defective in adipocyte plasma membranes from obese mice, is influenced by a different lipid environment in membranes from obese animals.
在瘦小鼠和肥胖（ob/ob）小鼠的脂肪细胞质膜中，氟化物和鸟嘌呤核苷酸刺激的腺苷酸环化酶活性的阿伦尼乌斯图呈线性。两组肝细胞质膜中异丙肾上腺素刺激的腺苷酸环化酶活性的阿伦尼乌斯图呈双相性。瘦小鼠膜中的结果呈双相性，而肥胖小鼠膜中的结果呈线性。相比之下，两组肝细胞质膜中胰高血糖素刺激的腺苷酸环化酶活性的阿伦尼乌斯图均呈双相性。结果表明，在肥胖小鼠脂肪细胞质膜中观察到的β受体与腺苷酸环化酶调节单位之间的偶联，受到肥胖动物膜中不同脂质环境的影响。
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