庆大霉素和西索米星对人单核细胞超氧化物生成的影响。
Effect of gentamicin and sisomicin on the generation of superoxide by human monocytes.
作者信息
Dri P, Menegazzi R, Pirotta F, Soranzo M R, Cramer R
出版信息
Chemioterapia. 1984 Jun;3(3):159-62.
The effect of gentamicin and sisomicin on the generation of superoxide anions by human monocytes exposed to a phagocytosing stimulus, i.e. serum treated zymosan, or a soluble stimulus, i.e. 4-beta-phorbol-12-myristate-13-acetate, has been studied. Neither sisomicin nor gentamicin affected the superoxide production by stimulated monocytes. The data suggest that the reported variability in the response to aminoglycoside antibiotic therapy in certain clinical situations cannot be attributed to interference with monocyte oxidative burst.
已经研究了庆大霉素和西索米星对受到吞噬刺激（即血清处理的酵母聚糖）或可溶性刺激（即4-β-佛波醇-12-肉豆蔻酸酯-13-乙酸酯）的人单核细胞产生超氧阴离子的影响。西索米星和庆大霉素均未影响受刺激单核细胞的超氧产生。数据表明，在某些临床情况下，报告的对氨基糖苷类抗生素治疗反应的变异性不能归因于对单核细胞氧化爆发的干扰。
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