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突触前刺激对神经元膜乙酰胆碱敏感性的修饰。

Modification of acetylcholine sensitivity of neuronal membrane by presynaptic stimulation.

作者信息

Arvanov V L, Salánki J, Ayrapetyan S N

出版信息

Gen Physiol Biophys. 1984 Dec;3(6):483-8.

PMID:6099299
Abstract

The action of electrical stimulation of one of the pallial nerves on the sensitivity of the bursting RPa1 neuron of Helix pomatia to acetylcholine (ACh) was investigated. The depolarizing effect of ACh was significantly decreased by presynaptic stimulation. Stimulation leads also to an attenuation of the ACh-induced increase in membrane conductivity. The effect of stimulation on the ACh evoked response of the membrane was reversibly blocked by cold and was completely eliminated after long term incubation of the neuron under "in vitro" conditions.

摘要

研究了电刺激一种脑皮层神经对苹果螺爆发性RPa1神经元对乙酰胆碱(ACh)敏感性的作用。突触前刺激可显著降低ACh的去极化作用。刺激还会导致ACh诱导的膜电导率增加减弱。刺激对膜的ACh诱发反应的影响可被低温可逆性阻断,并在神经元在“体外”条件下长期孵育后完全消除。

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