反向内肽类似物的固相合成。缓激肽增强肽BPP9a [gLys6, (RS)-mPhe7, Ala8] BPP9a的部分修饰反向内肽类似物的合成及生物活性。
Solid phase synthesis of retro-inverso peptide analogues. Synthesis and biological activity of the partially modified retro-inverso analogue of the bradykinin potentiating peptide BPP9a [gLys6, (RS)-mPhe7, Ala8] BPP9a.
作者信息
Bonelli F, Pessi A, Verdini A S
出版信息
Int J Pept Protein Res. 1984 Dec;24(6):553-6.
PMID:6099336
Abstract
The solid phase synthesis of a partially modified retro-inverso analogue of the bradykinin potentiating peptide BPP9a, [gLys6, (R,S)-mPhe7, Ala8] BPP9a is described. The analogue, which is active in vitro and in vivo, displays prolonged resistance towards cleavage by angiotensin converting enzyme (ACE).
摘要
描述了缓激肽增强肽BPP9a的部分修饰的反向模拟类似物[gLys6，（R，S）-mPhe7，Ala8] BPP9a的固相合成。该类似物在体外和体内均具有活性，对血管紧张素转换酶（ACE）的切割显示出更长的抗性。
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