β-内啡肽。不同链长的合成类似物在神经母细胞瘤x胶质瘤NG108-15细胞膜中的结合活性。
Beta-endorphin. Binding activity of synthetic analogs with various chain lengths in neuroblastoma x glioma NG108-15 cell membranes.
作者信息
Hammonds R G, Ferrara P, Li C H
出版信息
Int J Pept Protein Res. 1984 Dec;24(6):597-9.
PMID:6099337
Abstract
Inhibition of binding of beta h-endorphin or Leu-enkephalin by beta h-endorphin analogs of various chain lengths in memmbrane preparations of the neuroblastoma x glioma NG108-15 cells has been investigated. The removal of even a single residue from the C-terminus results in the inability of the resulting peptide to completely displace beta h-endorphin. In addition, the proportion of nondisplaceable binding increases with decreasing chain length.
摘要
研究了不同链长的β-内啡肽类似物在神经母细胞瘤x胶质瘤NG108-15细胞膜制剂中对β-内啡肽或亮氨酸脑啡肽结合的抑制作用。从C末端去除哪怕一个残基都会导致所得肽无法完全取代β-内啡肽。此外，不可取代结合的比例随着链长的缩短而增加。
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