Vella V
Ital J Neurol Sci. 1984 Dec;5(4):347-56. doi: 10.1007/BF02042616.
The geographic distribution of multiple sclerosis and the influence of migration on the risk of contracting it point to an environmental factor as cause of the disease. This environmental factor might be a virus which might produce the demyelination process through an autoimmune reaction against components of the central nervous system. The other possible cause of multiple sclerosis is a genetic susceptibility, inferred from the higher risk for the disease found among relatives of patients with multiple sclerosis and on the association between the disease and some histocompatibility antigens of the HLA system. Both theories seem to be correct, with the environmental factors(s) causing multiple sclerosis only in the presence of a genetic susceptibility.
多发性硬化症的地理分布以及移民对罹患该病风险的影响表明，环境因素是导致该疾病的原因。这种环境因素可能是一种病毒，它可能通过针对中枢神经系统成分的自身免疫反应引发脱髓鞘过程。多发性硬化症的另一个可能病因是遗传易感性，这是从多发性硬化症患者亲属中该病较高的发病风险以及该疾病与HLA系统某些组织相容性抗原之间的关联推断出来的。两种理论似乎都正确，环境因素只有在存在遗传易感性的情况下才会导致多发性硬化症。
