Garzón J, Schulz R, Herz A
Neuropeptides. 1984 Dec;5(1-3):101-4. doi: 10.1016/0143-4179(84)90037-4.
In the present study, we analyzed the interaction of concomitantly-acting pairs of opioid agonists in inhibiting the electrically induced contraction of the rat vas deferens (RVD). The results when compared with the predictions of the law of mass action and the receptor theory (1,2) provide evidence for a specific receptor for beta-endorphin (beta-EP) in this organ. This receptor is not occupied by the delta-agonist D-Ala2-D-Leu5-enkephalin (DADLE), or the mu-agonists Sandoz FK-33824, fentanyl and etorphine in the range of concentrations necessary for these to exert their maximal agonistic action in the test. The activity of beta-endorphin in the rat vas deferens is in agreement with the proposed existence (3,4) of the epsilon-type of opioid receptor therein.
在本研究中，我们分析了阿片类激动剂协同作用对抑制大鼠输精管（RVD）电诱导收缩的相互作用。与质量作用定律和受体理论（1,2）的预测结果相比，结果为该器官中β-内啡肽（β-EP）的特异性受体提供了证据。在这些物质在试验中发挥最大激动作用所需的浓度范围内，该受体未被δ-激动剂D-Ala2-D-Leu5-脑啡肽（DADLE）或μ-激动剂山德士FK-33824、芬太尼和埃托啡占据。大鼠输精管中β-内啡肽的活性与其中ε型阿片受体的存在提议（3,4）一致。
