对吗啡产生的肌肉强直形成耐受性并被刻板行为所取代。
Development of tolerance to the muscular rigidity produced by morphine and replacement by stereotypic behaviour.
作者信息
Themann P, Havemann U, Kuschinsky K
出版信息
Neuropeptides. 1984 Dec;5(1-3):27-8. doi: 10.1016/0143-4179(84)90018-0.
PMID:6099510
Abstract
After chronic treatment with morphine, the muscular rigidity mediated by opioid receptors in the striatum, was gradually replaced by stereotypic behaviour indicating an increased nigrostriatal dopaminergic activity. These results suggest that one behavioural pattern, originating in the striatum, was replaced by another one, which is antagonistic to the first one.
摘要
长期使用吗啡治疗后，纹状体中由阿片受体介导的肌肉强直逐渐被刻板行为所取代，这表明黑质纹状体多巴胺能活性增强。这些结果表明，一种起源于纹状体的行为模式被另一种与第一种行为模式相反的行为模式所取代。
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