梗死灶摄取亲心肌剂的急性摄取和慢性滞留：99锝焦磷酸盐和125碘苯磷酸盐。

Acute uptake and chronic retention of infarct avid myocardial-seeking agents: 99Tcm-pyrophosphate and 125I-phenylphosphate.

作者信息

Castronovo F P, Yasuda T, Strauss H W

出版信息

Nucl Med Commun. 1984 Oct;5(10):647-54. doi: 10.1097/00006231-198410000-00007.

DOI:10.1097/00006231-198410000-00007

Abstract

The concentration of 125I-phenylphosphate (I phi PA), a long-lived bone-seeking radio-pharmaceutical (T1/2 biol = 962 days) that localizes in acute infarction (MI), was studied in 30 rats after ligation of the anterior descending coronary artery. At 23 h postMI, I phi PA was given intravenously to all animals, and five of this group received 99Tcm-pyrophosphate (99Tcm-pyro) intravenously. These five rats were sacrificed 2 h later and the content of I phi PA and 99Tcm-pyro activities was determined for normal and infarcted (INF) heart segments. There is a zone of INF that contains residual I phi PA which also concentrates 99Tcm-pyro consistently after MI. This zone may represent jeopardized myocardium which has not undergone complete necrosis.

摘要

125I-苯磷酸盐（I phi PA）是一种长寿命的亲骨性放射性药物（生物半衰期T1/2 = 962天），可定位于急性梗死（心肌梗死，MI）区域。本研究对30只大鼠进行冠状动脉前降支结扎术后，研究了I phi PA的浓度。心肌梗死后23小时，对所有动物静脉注射I phi PA，其中5只大鼠还静脉注射了99锝焦磷酸盐（99Tcm-焦磷酸盐）。2小时后处死这5只大鼠，测定正常和梗死（INF）心脏节段的I phi PA含量和99Tcm-焦磷酸盐活性。梗死区域存在一个含有残留I phi PA的区域，心肌梗死后该区域也始终聚集99Tcm-焦磷酸盐。该区域可能代表尚未发生完全坏死的濒危心肌。