Czarniecki C W, Allen P T
Antiviral Res. 1984 Dec;4(6):351-5. doi: 10.1016/0166-3542(84)90006-8.
JLS-V9R cells, a Balb/c mouse bone marrow cell line chronically infected with Rauscher leukemia virus, were treated with mouse interferon and inoculated with several different lytic viruses. Relatively low interferon concentrations protected the cells against Sindbis virus, vesicular stomatitis virus and MM virus. In contrast, encephalomyocarditis virus replication was inhibited by less than 1 log even with an interferon concentration of 1000 U/ml. These findings provide further evidence that interferon-induced antiviral effects are mediated through multiple mechanisms and demonstrate that even viruses which are classified within the same family (MM and encephalomyocarditis virus) can exhibit differential interferon sensitivities.
JLS-V9R细胞是一种长期感染劳斯氏白血病病毒的Balb/c小鼠骨髓细胞系，用小鼠干扰素处理后接种几种不同的裂解病毒。相对较低浓度的干扰素可保护细胞免受辛德毕斯病毒、水泡性口炎病毒和MM病毒的侵害。相比之下，即使干扰素浓度达到1000 U/ml，脑心肌炎病毒的复制也仅被抑制不到1个对数。这些发现进一步证明干扰素诱导的抗病毒作用是通过多种机制介导的，并表明即使属于同一家族的病毒（MM病毒和脑心肌炎病毒）也可能表现出不同的干扰素敏感性。
