Mentkevich L M, Zhdanova L V, Meshkova E N
Vopr Virusol. 1984 Sep-Oct;29(5):582-5.
A comparative study of the antiviral effect of human immune and leukocyte interferons in homologous diploid cells showed that the resistant condition of the cells produced by interferon depended on the type and concentration of the inhibitor, its presence in the culture medium and time of action on the cells. Reproduction of EMC virus and its cytopathic effect were inhibited to a much greater extent when the cells were treated with leukocyte interferon. The resistance of the cells in both cases was evident as early as one hour after their contact with interferon. The resistance of the cells induced by leukocyte interferon was of longer duration than after induction with immune interferon (greater than 72 h and approximately 48 h, respectively).
在同源二倍体细胞中对人免疫干扰素和白细胞干扰素抗病毒作用的比较研究表明，干扰素产生的细胞抗性状况取决于抑制剂的类型和浓度、其在培养基中的存在情况以及对细胞的作用时间。当用白细胞干扰素处理细胞时，EMC病毒的复制及其细胞病变效应受到的抑制程度要大得多。在这两种情况下，细胞与干扰素接触后仅一小时就表现出抗性。白细胞干扰素诱导的细胞抗性持续时间比免疫干扰素诱导后的持续时间更长（分别大于72小时和约48小时）。
