Khachaturian H, Lewis M E, Haber S N, Akil H, Watson S J
Brain Res Bull. 1984 Dec;13(6):785-800. doi: 10.1016/0361-9230(84)90237-5.
The immunocytochemical distribution of proopiomelanocortin (POMC) peptides (beta-endorphin, ACTH, alpha-MSH, 16K fragment) was studied in the brain of the rhesus monkey (Macaca mulatta). Some animals were administered colchicine intracerebroventricularly prior to sacrifice to enhance the visualization of perikaryal immunoreactivity. Immunoreactive perikarya are localized to hypothalamic infundibular nucleus, giving rise to several distinct projections. Rostral projections extend through midline diencephalic and preoptic areas, and enter the telencephalon. Along this course, immunoreactive fibers are seen in midline hypothalamic and preoptic nuclei, nucleus of the diagonal band, olfactory tubercle, nucleus accumbens, bed nucleus of stria terminalis, septum, and other limbic structures in telencephalon. Caudal to the anterior commissure, some fibers ascend dorsally to enter the midline thalamus, which they innervate. Lateral projections of the infundibular perikarya course through the medial-basal hypothalamus, dorsal to the optic tracts, and enter the amygdala region where they innervate more medially situated amygdaloid nuclei. Caudal projections of the POMC neurons also extend through midline diencephalon, some coursing along a periventricular path to innervate midline hypothalamic and thalamic nuclei. This projection extends into the mesencephalic substantia grisea centralis and may also contribute to the innervation of more dorsally situated nuclei in the pons and medulla, such as the parabrachial nuclei and nucleus tractus solitarius. Other caudal projections originating in the hypothalamus course through the ventral tegmentum of mesencephalon and pons and may contribute to the innervation of midline raphe and other ventrally situated nuclei in the pons and medulla. The distribution of immunoreactive perikarya and fibers in the brain of rhesus monkey is strikingly similar to that found in the rat brain. However, subtle differences appear to exist in the innervation patterns of particular brain regions.
在恒河猴（猕猴）脑中研究了阿片促黑激素皮质素原（POMC）肽（β-内啡肽、促肾上腺皮质激素、α-促黑素、16K片段）的免疫细胞化学分布。一些动物在处死前经脑室内注射秋水仙碱，以增强核周免疫反应性的可视化。免疫反应性核周体定位于下丘脑漏斗核，产生几种不同的投射。向前投射穿过间脑中线和视前区，进入端脑。在此过程中，在中线下丘脑和视前核、斜角带核、嗅结节、伏隔核、终纹床核、隔区以及端脑的其他边缘结构中可见免疫反应性纤维。在前连合尾侧，一些纤维背侧上升进入中线丘脑并支配该区域。漏斗核周体的外侧投射穿过内侧基底下丘脑，在视束背侧，进入杏仁核区域并支配更内侧的杏仁核。POMC神经元的尾侧投射也穿过间脑中线，一些沿脑室周路径走行以支配中线下丘脑和丘脑核。该投射延伸至中脑中央灰质，也可能有助于支配脑桥和延髓中更靠背侧的核，如臂旁核和孤束核。起源于下丘脑的其他尾侧投射穿过中脑和脑桥的腹侧被盖，可能有助于支配脑桥和延髓中线的中缝核及其他位于腹侧的核。恒河猴脑中免疫反应性核周体和纤维的分布与大鼠脑中的分布惊人地相似。然而，在特定脑区的神经支配模式上似乎存在细微差异。
