巴氯芬的突触后作用与其对海马中荷包牡丹碱诱导的癫痫发生的拮抗作用相关。
Postsynaptic actions of baclofen associated with its antagonism of bicuculline-induced epileptogenesis in hippocampus.
作者信息
Brady R J, Swann J W
出版信息
Cell Mol Neurobiol. 1984 Dec;4(4):403-8. doi: 10.1007/BF00733601.
Abstract
The effect of baclofen on bicuculline-induced epileptogenesis was investigated in the CA3 region of hippocampal slices taken from rats 9 days to 8 weeks of age. Bath application of baclofen blocked all spontaneous epileptiform activity and raised the stimulus strength required for orthodromic induction of epileptiform discharges. Baclofen was equally effective in antagonizing depolarization shift generation in mature and immature rat slices. The duration of afterdischarges recorded in immature hippocampus was unaltered, yet these events were eliminated when the proceeding depolarization shift was blocked. Baclofen hyperpolarized all CA3 pyramidal cells studied with an associated decrease in membrane resistance. These effects were produced by a direct postsynaptic action.
摘要
研究了巴氯芬对9日龄至8周龄大鼠海马切片CA3区荷包牡丹碱诱导的癫痫发生的影响。浴用巴氯芬可阻断所有自发性癫痫样活动，并提高诱发癫痫样放电的正向刺激强度。巴氯芬在拮抗成熟和未成熟大鼠切片中的去极化偏移产生方面同样有效。在未成熟海马中记录的放电后持续时间未改变，但当先前的去极化偏移被阻断时，这些事件被消除。巴氯芬使所有研究的CA3锥体细胞超极化，同时膜电阻降低。这些作用是由直接的突触后作用产生的。
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Selective depression of synaptic excitation in cat spinal neurones by baclofen: an iontophoretic study.巴氯芬对猫脊髓神经元突触兴奋的选择性抑制作用：一项离子电泳研究。
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