Papaleo C, Carella C, Zito G A, Figlia A, Capuano F, Amato G
Chemioterapia. 1984 Aug;3(4):220-2.
The effects of medroxyprogesterone acetate (MPA) at high dosages on ACTH and cortisol plasma levels have been studied on seven patients which were carriers of ER+ and PR+ neoplasm. ACTH and cortisol plasma levels were studied at 8:00 a.m., before and after a 4-week treatment with MPA at dosages of 1000 mg/die at basal conditions and after a metyrapone stimulation test. The results obtained show that the MPA treatment causes a highly significant drop of both cortisol and ACTH plasma levels. The metyrapone stimulation test performed before and after MPA treatment confirms the suppressive effect of MPA on the hypothalamus-pituitary-adrenal gland axis. These data suggest a cortisol-like action of MPA with a negative feed-back mechanism on the hypothalamus-pituitary-adrenal gland axis.
已对7名患有雌激素受体阳性（ER+）和孕激素受体阳性（PR+）肿瘤的患者研究了高剂量醋酸甲羟孕酮（MPA）对促肾上腺皮质激素（ACTH）和血浆皮质醇水平的影响。在基础条件下，于上午8点，在给予剂量为1000mg/日的MPA进行4周治疗之前和之后，以及在甲吡酮刺激试验之后，研究了ACTH和血浆皮质醇水平。获得的结果表明，MPA治疗导致皮质醇和ACTH血浆水平均显著下降。在MPA治疗前后进行的甲吡酮刺激试验证实了MPA对下丘脑-垂体-肾上腺轴的抑制作用。这些数据表明MPA具有类似皮质醇的作用，并对下丘脑-垂体-肾上腺轴具有负反馈机制。
