Scheid P, Meyer M, Piiper J
Adv Exp Med Biol. 1984;180:65-72. doi: 10.1007/978-1-4684-4895-5_5.
Inert gas washout from tissue may be analyzed using Krogh's cylinder or a simplified model thereof, represented by a series arrangement of compartments. In particular with limited axial diffusion in tissue, washout from this model is multi-exponential, the rate of washout accelerating with time. To explain the experimentally observed multicomponent washout, in which washout retards with time, heterogeneity of flow and/or diffusing capacity to volume is required, either in series or in parallel compartments. While there appears to be a structural basis for both types of heterogeneity, parallel and series, a distinction between both on the basis of washout curves alone is impossible.
组织中的惰性气体清除可使用克勒格氏圆筒模型或其简化模型进行分析，该简化模型由一系列相互串联的隔室表示。特别是在组织中轴向扩散受限的情况下，该模型的清除是多指数的，清除速率随时间加快。为了解释实验观察到的多组分清除现象（即清除随时间减缓），需要在串联或并联隔室中存在流量和/或扩散能力与体积的异质性。虽然似乎平行和串联这两种异质性类型都有结构基础，但仅根据清除曲线无法区分两者。
