Mazzei T, Marino C, Nozzoli F, Lopes-Pegna A, Righi R, Santomaggio C, Lamanna S, Periti P
Chemioterapia. 1984 Feb;3(1):16-8.
The authors investigated the activity of a combination of DDP 80 mg/m2 i.v. followed by VP16 50 mg/m2 on days 2-5 in bronchogenic carcinoma. Twenty-seven patients entered the study (10 small cell carcinoma, 9 squamous cell, 2 adenocarcinomas and 6 histologically undefined). Six patients evidenced partial response (22.3%); one patient (small cell) had complete remission. The toxicity of the regimen was scarce and well-tolerated by patients with an incidence of 88.8% alopecia, and 77.7% nausea and/or vomiting.
作者研究了在支气管源性癌中，先静脉注射80mg/m²顺铂（DDP），随后在第2至5天静脉注射50mg/m²依托泊苷（VP16）的联合治疗活性。27例患者进入该研究（10例小细胞癌、9例鳞状细胞癌、2例腺癌和6例组织学未明确的癌）。6例患者显示部分缓解（22.3%）；1例患者（小细胞癌）完全缓解。该治疗方案毒性轻微，患者耐受性良好，脱发发生率为88.8%，恶心和/或呕吐发生率为77.7%。
