Szendröi Z
Int Urol Nephrol. 1984;16(4):327-35. doi: 10.1007/BF02081869.
Two different hormonal gestagens, cyproterone acetate and norethisterone, were studied in prostatic carcinoma, for the greatest part in advanced cases. Cyproterone acetate was administered to 80, norethisterone to 38 unselected patients. The period of study extended over 2 years or more. The mechanism of action of gestagens and the role of the hormone receptors are discussed. The significance of serial measurements of plasma testosterone by providing a monitor of hormonal therapy is emphasized. The relevant literature is reviewed. The value of gestagens as an alternative to the traditional hormone therapy of prostatic carcinoma is pointed out.
在前列腺癌患者中，尤其是晚期患者，对两种不同的激素性孕激素——醋酸环丙孕酮和炔诺酮进行了研究。80例患者使用醋酸环丙孕酮，38例未经挑选的患者使用炔诺酮。研究期超过2年。文中讨论了孕激素的作用机制以及激素受体的作用。强调了通过连续测量血浆睾酮为激素治疗提供监测的重要性。回顾了相关文献。指出了孕激素作为前列腺癌传统激素治疗替代方法的价值。
