Frisina N, Buemi M, Macri' I
Ann Endocrinol (Paris). 1984;45(6):387-91.
We studied the effects of infusion of dopamine (4 microgram/kg/min for 120 min) alone or with domperidone infusion (235 microgram/min for 120 min) on aldosterone secretion before and after stimulation by ACTH (0,5 mg i.v.) in normal subjects. We also studied the effects, of pimozide (12 mg p.o.), of domperidone infusion (235 microgram/min for 120 min) before and after stimulation with ACTH (0,5 mg i.v.) on aldosterone secretion in two other sets of normal subjects. The infusion of dopamine does not modify the basal secretion of aldosterone whereas in other trials it caused reduction (P less than 0,05) of blood aldosterone response to ACTH versus controls. Domperidone and pimozide, D2 antagonist, do not modify the aldosterone secretion before and after ACTH stimulation. Furthermore domperidone does not remove inhibition of dopamine on aldosterone response to ACTH. We can exclude an action of central or peripheral D2 dopaminergic receptors in aldosterone secretion in man. Dopamine, which does not cross the blood brain barrier, reduced the blood aldosterone response to ACTH; for those reasons we can hypothesize that receptors D1, stimulated by dopamine modulate aldosterone secretion.
我们研究了在正常受试者中，单独输注多巴胺（4微克/千克/分钟，持续120分钟）或与多潘立酮联合输注（235微克/分钟，持续120分钟）对促肾上腺皮质激素（0.5毫克静脉注射）刺激前后醛固酮分泌的影响。我们还研究了在另外两组正常受试者中，匹莫齐特（12毫克口服）、多潘立酮输注（235微克/分钟，持续120分钟）在促肾上腺皮质激素（0.5毫克静脉注射）刺激前后对醛固酮分泌的影响。输注多巴胺不会改变醛固酮的基础分泌，而在其他试验中，与对照组相比，它会导致血液中醛固酮对促肾上腺皮质激素的反应降低（P<0.05）。多潘立酮和匹莫齐特（D2拮抗剂）在促肾上腺皮质激素刺激前后均不会改变醛固酮分泌。此外，多潘立酮不会消除多巴胺对醛固酮对促肾上腺皮质激素反应的抑制作用。我们可以排除中枢或外周D2多巴胺能受体在人类醛固酮分泌中的作用。多巴胺不能穿过血脑屏障，它降低了血液中醛固酮对促肾上腺皮质激素的反应；基于这些原因，我们可以推测，受多巴胺刺激的D1受体调节醛固酮分泌。
