Continsouza-Blanc D, Elghozi J L, Dausse J P
J Hypertens Suppl. 1984 Dec;2(3):S155-7.
We have previously demonstrated an alteration in cerebral and renal alpha 2-adrenoceptor densities in hypertensive rats. Since human platelets contain alpha 2-adrenoceptors, these receptors were measured in normotensive and hypertensive subjects using [3H]-rauwolscine to determine whether there was an alteration of alpha 2-adrenoceptors in human hypertension. In normotensive subjects, [3H]-rauwolscine bound to distinct high- and low-affinity alpha 2-adrenoceptor sites. In contrast, in platelets of hypertensive patients only the high-affinity alpha 2-adrenoceptor site was detectable. In addition, platelet alpha 2-adrenoceptor densities were higher in normotensive than in hypertensive subjects. This alteration, if present in other cells, could be important in the pathogenesis of hypertension.
我们先前已证明高血压大鼠脑和肾中的α2-肾上腺素能受体密度发生了改变。由于人类血小板含有α2-肾上腺素能受体，因此使用[3H]-萝芙辛在血压正常和高血压受试者中测量这些受体，以确定人类高血压中α2-肾上腺素能受体是否发生改变。在血压正常的受试者中，[3H]-萝芙辛与不同的高亲和力和低亲和力α2-肾上腺素能受体位点结合。相比之下，在高血压患者的血小板中，仅可检测到高亲和力α2-肾上腺素能受体位点。此外，血压正常受试者的血小板α2-肾上腺素能受体密度高于高血压受试者。这种改变若存在于其他细胞中，可能在高血压的发病机制中起重要作用。
