Corvol P, Michel J B, Evin G, Gardes J, Bensala-Alaoui A, Ménard J
J Hypertens Suppl. 1984 Dec;2(2):S25-30.
The role of the renin-angiotensin system in the control of blood pressure in normal rodents, primates and man has been evaluated using inhibitors which block the system at various stages. Renin plays a major role in the maintenance of blood pressure under volume depletion. In subjects with a normal salt intake, the contribution of the renin-angiotensin system in maintaining blood pressure levels can be evaluated using angiotensin converting enzyme (ACE) inhibitors. The contribution of the renin-angiotensin system can now be evaluated more closely following the development of new substances which block the renin-angiotensinogen reaction. Available data strongly suggest that renin contributes to the maintenance of blood pressure levels in subjects with a normal salt intake, although to a lesser degree than in subjects on a low sodium intake. The renin-angiotensin system plays a role in the regulation of blood pressure levels in normal experimental animals and man--its importance depending on the state of sodium balance.
肾素-血管紧张素系统在正常啮齿动物、灵长类动物和人类血压控制中的作用，已通过在不同阶段阻断该系统的抑制剂进行了评估。肾素在容量耗竭时维持血压方面起主要作用。在盐摄入量正常的受试者中，可使用血管紧张素转换酶（ACE）抑制剂来评估肾素-血管紧张素系统在维持血压水平中的作用。随着能够阻断肾素-血管紧张素原反应的新物质的开发，现在可以更精确地评估肾素-血管紧张素系统的作用。现有数据有力地表明，肾素有助于维持盐摄入量正常的受试者的血压水平，尽管其程度低于低钠摄入的受试者。肾素-血管紧张素系统在正常实验动物和人类的血压水平调节中起作用——其重要性取决于钠平衡状态。
