Sieg J W, Robinson J R
School of Pharmacy, University of Wisconsin, Madison 53706.
J Pharm Sci. 1981 Sep;70(9):1026-9. doi: 10.1002/jps.2600700915.
The mechanism of corneal fluorometholone penetration was studied using albino rabbits, and the apparent rate and extent of steroid accumulation in the various cell layers of the cornea and aqueous humor were determined for normal and abraded eyes. The results are compared and contrasted to the mechanism previously reported for pilocarpine. Fluorometholone readily penetrates the intact corneal epithelium and accumulates in the hydrophilic stromal layers of the cornea. The kinetic profile is similar to that of pilocarpine and is largely a result of the pre-corneal dynamic processes. Pharmacokinetic parameters for each tissue were determined to establish an overall mechanism for corneal permeation of the steroid.
利用白化兔研究了氟米龙的角膜渗透机制，并测定了正常眼和磨损眼的角膜各细胞层及房水中类固醇的表观蓄积速率和程度。将结果与先前报道的毛果芸香碱的机制进行了比较和对比。氟米龙很容易穿透完整的角膜上皮，并蓄积在角膜的亲水性基质层中。动力学特征与毛果芸香碱相似，主要是角膜前动态过程的结果。确定了每个组织的药代动力学参数，以建立类固醇角膜渗透的总体机制。
