Large M S, Smith L H
J Med Chem. 1980 Feb;23(2):112-7. doi: 10.1021/jm00176a002.
The synthesis of a series of derivatives of 1-phenyl-2-[[(substituted amido)alkyl]amino]ethanols is described. The compounds were investigated for beta-adrenoceptor blocking properties, and many showed a surprising degree of potency and beta 1-cardioselectivity when tested in vivo in anesthetized cats. The structure-activity relationships shown by this series of compounds are discussed and related to known beta-adrenergic blocking agents.
