超低剂量静脉注射肝素预防术后深静脉血栓形成
Ultra-low dose intravenous heparin in the prevention of postoperative deep-vein thrombosis.
作者信息
Negus D, Friedgood A, Cox S J, Peel A L, Wells B W
出版信息
Lancet. 1980 Apr 26;1(8174):891-4. doi: 10.1016/s0140-6736(80)90834-x.
PMID:6103255
Abstract
Heparin (1 IU kg-1 h-1) given intravenously for 3-5 days during and after operation in a double-blind randomised study, significantly reduced the frequency of deep-vein thrombosis detected by 125I-fibrinogen uptake, and pulmonary embolism. 22% (11/50) control patients and 4% (2/45) patients receiving heparin had deep-vein thrombosis or pulmonary embolism. Heparin administration was not associated with any increase in preoperative or postoperative bleeding.
摘要
在一项双盲随机研究中，术后及术中静脉注射肝素（1国际单位/千克/小时），持续3至5天，显著降低了通过¹²⁵I - 纤维蛋白原摄取检测到的深静脉血栓形成频率以及肺栓塞发生率。对照组50例患者中有22%（11/50）发生深静脉血栓形成或肺栓塞，而接受肝素治疗的45例患者中这一比例为4%（2/45）。给予肝素与术前或术后出血增加无关。
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