Negus D
Ann R Coll Surg Engl. 1985 May;67(3):144-8.
Venous ulcers are related to incompetence of the direct calf and ankle perforating veins, the majority of which follow deep vein thrombosis. Prevention of the latter by intravenous micro-dose heparin (1 unit/kg/hour) is effective, safe and inexpensive. Its efficacy has been proved in two controlled clinical trials. Venous ulcers have been treated by perforating vein ligation, with saphenous ligation and stripping where necessary, and with the addition of permanent knee-length elastic compression stockings in patients with femoro-popliteal incompetence. This regimen has achieved a 92% long-term success rate in patients without rheumatoid arthritis.
静脉溃疡与小腿直接和踝部穿通静脉功能不全有关，其中大多数继发于深静脉血栓形成。通过静脉输注微剂量肝素（1单位/千克/小时）预防深静脉血栓形成有效、安全且费用低廉。其疗效已在两项对照临床试验中得到证实。静脉溃疡的治疗方法包括结扎穿通静脉，必要时结扎和剥脱大隐静脉，并对股腘静脉功能不全的患者加用长及膝盖的永久性弹力压迫袜。该治疗方案在无类风湿关节炎的患者中取得了92%的长期成功率。
