Bussolino F, Camussi G, Ragni R, Masera C, Rotunno M, Vercellone A
Minerva Med. 1980 Mar 24;71(11):835-40.
The tissue damage during the inflammation is determined by the enzymes and the mediators of anaphylaxis released from polymorphonuclear cells (PMN), platelets, basophils and mastocytes. The control of this release involves the cAMP and cGMP. The cyclic nucleotides independently or synergically regulate the polymerisation of the microtubules and the microfilaments. Drugs increasing the intracellular concentration of cAMP or cGMP inhibit or enhance respectively the enzymatic release from PMN, basophils and mastocytes. In the platelets, cAMP plays a very important role, whereas the cGMP function is controversial.
炎症过程中的组织损伤由多形核细胞（PMN）、血小板、嗜碱性粒细胞和肥大细胞释放的酶及过敏反应介质所决定。这种释放的控制涉及环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）。环核苷酸独立或协同调节微管和微丝的聚合。增加细胞内cAMP或cGMP浓度的药物分别抑制或增强PMN、嗜碱性粒细胞和肥大细胞的酶释放。在血小板中，cAMP起着非常重要的作用，而cGMP的功能则存在争议。
