Romanski B, Broda S
Allergol Immunopathol (Madr). 1977 Nov-Dec;5(6):659-62.
A study on the presence of specific precipitins against tobacco antigens was done in a population of 361 healthy cigrette smokers and in a group of 60 healthy non-smokers. The tests were made by the gel diffusion technique of Ouchterlony using tobacco extract prepared by the Coca method. A positive precipitation reaction was observed in 11.8 per cent of the smokers' sera examined but never in the non-smokers group. The reaction occurred in subjects of both sexes and was neither dependent upon how long they had smoked nor on the number of cigarettes smoked daily. In the authors' opinion, the formation of precipitins against tobacco antigens may be the result of a sensitivity reaction. It is therefore possible that in predisposed individuals immune complexes of precipitins and tobacco antigens may be formed. They could be responsible for some cardiovascular disorders occuring in smokers. In order to confirm such a hypothesis, a study was carried out recently by the authors on a large group of patients suffering from coronary disease.
对361名健康吸烟者和60名健康非吸烟者进行了一项针对烟草抗原特异性沉淀素存在情况的研究。检测采用奥克特洛尼凝胶扩散技术，使用可口法制备的烟草提取物。在所检测的吸烟者血清中，11.8%观察到阳性沉淀反应，而在非吸烟者组中从未观察到。该反应在男女受试者中均有发生，既不取决于他们吸烟的时长，也不取决于每日吸烟的数量。作者认为，针对烟草抗原的沉淀素形成可能是过敏反应的结果。因此，在易感个体中可能会形成沉淀素与烟草抗原的免疫复合物。它们可能是吸烟者中发生的一些心血管疾病的病因。为了证实这一假设，作者最近对一大组冠心病患者进行了研究。
