Krishnan H, Baquer N Z, Singh R
Res Commun Chem Pathol Pharmacol. 1980 Mar;27(3):615-8.
Ketamine produced a significant reduction in synaptosomal Na+-K+ ATPase activity both in vivo as well as in vitro. The in vitro inhibition was non-competitive. The observed inhibition of this enzyme may play a significant role in the neurotransmitter events at synapses.
氯胺酮在体内和体外均能显著降低突触体钠钾ATP酶的活性。体外抑制作用是非竞争性的。观察到的这种酶的抑制作用可能在突触处的神经递质活动中发挥重要作用。