Tang C Y
Zhonghua Yu Fang Yi Xue Za Zhi. 1989 Mar;23(2):80-2.
In vitro Effect of several pyrethroids on rat brain synaptosomal ATPase activities was investigated. No significant changes in Na+, K+-ATPase and oligomycin-insensitive Mg2+-ATPase activities were observed under present experimental conditions, but all pyrethroids tested caused significant inhibition of oligomycin-sensitive Mg2+-ATPase activity with certain concentration dependence. The results suggest a possibility that pyrethroids may alter the cellular energy metabolism of the nervous system.
研究了几种拟除虫菊酯对大鼠脑突触体ATP酶活性的体外作用。在目前的实验条件下,未观察到Na +、K + -ATP酶和对寡霉素不敏感的Mg2 + -ATP酶活性有显著变化,但所有测试的拟除虫菊酯在一定浓度依赖性下均导致对寡霉素敏感的Mg2 + -ATP酶活性受到显著抑制。结果提示拟除虫菊酯可能改变神经系统的细胞能量代谢。