Prasad R, Patel V, Chansouria J P, Udupa K N
Endocrinol Exp. 1980;14(2):147-50.
The administration of pargyline to normal rats enhanced the adrenal catecholamines noradrenaline + adrenaline content, tyrosine hydroxylase (TH) and catechol -0-methyl transferase (COMT) activity together with a reduction in monoamine oxidase (MAO) activity. The pargyline pretreated rats exposed to acute stress exhibited a significant increase in adrenal catecholamine content and COMT activity with no change in TH and phenylethanolamine-N-emthyl transferase (PNMT) activity as compared to normal stressed rats. However, adrenal MAO activity was decreased in pargyline pretreated stressed rats. Thus, these observations tend to suggest that pargyline treatment before exposure to stress considerably influence the usual stress response in term of catecholamine metabolism.
给正常大鼠施用帕吉林可提高肾上腺儿茶酚胺（去甲肾上腺素 + 肾上腺素）含量、酪氨酸羟化酶（TH）和儿茶酚 -O- 甲基转移酶（COMT）活性，同时单胺氧化酶（MAO）活性降低。与正常应激大鼠相比，经帕吉林预处理的大鼠暴露于急性应激后，肾上腺儿茶酚胺含量和COMT活性显著增加，而TH和苯乙醇胺 -N- 甲基转移酶（PNMT）活性无变化。然而，经帕吉林预处理的应激大鼠肾上腺MAO活性降低。因此，这些观察结果倾向于表明，在暴露于应激之前进行帕吉林治疗会在儿茶酚胺代谢方面对通常的应激反应产生相当大的影响。
