Vesely D L, Rochat M H
Res Commun Chem Pathol Pharmacol. 1980 Apr;28(1):123-32.
In vivo injections of gibberellic acid, a potent plant growth hormone, are known to increase the growth of animals as well as plants. Investigation into gibberellic acid's growth promoting mechanism in animals at the cellular level focused on guanylate cyclase (E.C.4.6.1.2.), an enzyme known to be associated with growth. Gibberellic acid enhanced the activity of rat lung guanylate cyclase over a concentration range of .00001 mM to 1 mM with no stimulation being observed at .000001 mM. Varying the concentration of the guanylate cyclase co-factor manganese had no effect on gibberellic acid's enhancement of guanylate cyclase activity. Since human and rat growth hormones also enhance guanylate cyclase activity, it appears that at cellular level the mechanism of action of growth promoting hormones may include a common process that involves enhancement of guanylate cyclase activity.
已知在体内注射赤霉素（一种有效的植物生长激素）会促进动植物的生长。在细胞水平上对赤霉素在动物体内的生长促进机制进行的研究集中在鸟苷酸环化酶（E.C.4.6.1.2.）上，这是一种已知与生长相关的酶。赤霉素在0.00001 mM至1 mM的浓度范围内增强了大鼠肺鸟苷酸环化酶的活性，而在0.000001 mM时未观察到刺激作用。改变鸟苷酸环化酶辅因子锰的浓度对赤霉素增强鸟苷酸环化酶活性没有影响。由于人类和大鼠生长激素也能增强鸟苷酸环化酶活性，因此在细胞水平上，生长促进激素的作用机制似乎可能包括一个涉及增强鸟苷酸环化酶活性的共同过程。
