Welch W M, Ewing F E, Harbert C A, Weissman A, Koe B K
J Med Chem. 1980 Aug;23(8):949-52. doi: 10.1021/jm00182a025.
The preparation and testing of the two racemic diastereoisomers and the four optically active enantiomers of the title compound in in vitro and in vivo models for determining potential antipsychotic activity are described. Both racemic diastereoisomers and two of the four chiral enantiomers are potent and long-acting neuroleptic compounds.
本文描述了标题化合物的两种外消旋非对映异构体和四种旋光对映体在体外和体内模型中用于测定潜在抗精神病活性的制备和测试。两种外消旋非对映异构体和四种手性对映体中的两种都是强效且长效的抗精神病化合物。
