扁桃体切除术与儿童霍奇金病

Tonsillectomy and childhood Hodgkin's disease.

作者信息

Vianna N J, Lawrence C E, Davies J N, Arbuckle J, Harris S, Marani W, Wilkinson J

出版信息

Lancet. 1980 Aug 16;2(8190):338-40. doi: 10.1016/s0140-6736(80)90339-6.

Abstract

The relation between previous tonsillectomy and Hodgkin's disease was examined in a case-control study involving 81 histologically confirmed childhood cases and two sibling control groups. When cases were compared with age-matched sibling controls a significant association (p < 0.02), with a risk of 2.7, was observed for children who had undergone tonsillectomy. A significant association (p < 0.01), with a relative risk of 2.5, was also shown when all siblings were used for comparison. History of hospital admissions, age at tonsillectomy, Rye histological subtype, birth order, and sibship size did not appear to modify the effect of this operative procedure on the risk of Hodgkin's disease.

摘要

在一项病例对照研究中，对81例经组织学确诊的儿童霍奇金病病例以及两个同胞对照组进行了先前扁桃体切除术与霍奇金病之间关系的研究。当将病例与年龄匹配的同胞对照进行比较时，发现接受过扁桃体切除术的儿童存在显著关联（p < 0.02），风险为2.7。当使用所有同胞进行比较时，也显示出显著关联（p < 0.01），相对风险为2.5。住院史、扁桃体切除时的年龄、Rye组织学亚型、出生顺序和同胞数量似乎并未改变该手术对霍奇金病风险的影响。