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Difference of effective antitrypanosomal dosages of benznidazole in mice and man. Chemotherapeutic and pharmacokinetic results.

作者信息

Richle R W, Raaflaub J

出版信息

Acta Trop. 1980 Sep;37(3):257-61.

PMID:6106364
Abstract
摘要

相似文献

1
Difference of effective antitrypanosomal dosages of benznidazole in mice and man. Chemotherapeutic and pharmacokinetic results.小鼠与人中苯硝唑有效抗锥虫剂量的差异。化疗及药代动力学结果。
Acta Trop. 1980 Sep;37(3):257-61.
2
Multiple-dose kinetics of the trypanosomicide benznidazole in man.
Arzneimittelforschung. 1980;30(12):2192-4.
3
[Benznidazole and chronic Chagas disease].[苯硝唑与慢性恰加斯病]
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4
Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy.在实验性恰加斯病的慢性期，使用苯硝唑或硫利达嗪进行治疗可改善心脏病。
Int J Antimicrob Agents. 2007 Jun;29(6):733-7. doi: 10.1016/j.ijantimicag.2007.01.014. Epub 2007 Mar 28.
5
Benznidazole, a drug used in Chagas' disease, ameliorates LPS-induced inflammatory response in mice.苯硝唑是一种用于治疗恰加斯病的药物，可改善脂多糖诱导的小鼠炎症反应。
Life Sci. 2004 Dec 24;76(6):685-97. doi: 10.1016/j.lfs.2004.09.013.
6
[Clinico-therapeutic trial with benzonidazole in Chagas' disease].
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7
Chronic Chagas' disease in the mouse. IV. Effect of trypanocidal drugs.小鼠慢性恰加斯病。IV. 杀锥虫药物的作用。
Medicina (B Aires). 1983;43(2):126-30.
8
[Benzonidazole: one of the rare treatment for Chagas disease].
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9
[Treatment of chronic Chagas' disease. Is the etiological treatment effective?].[慢性恰加斯病的治疗。病因治疗是否有效？]
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Treatment of experimental chronic chagas disease with trifluralin.用氟乐灵治疗实验性慢性恰加斯病。
Basic Clin Pharmacol Toxicol. 2006 Apr;98(4):351-6. doi: 10.1111/j.1742-7843.2006.pto_253.x.

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Pharmacokinetic-pharmacodynamic modeling of benznidazole and its antitrypanosomal activity in a murine model of chronic Chagas disease.苯硝唑在慢性恰加斯病小鼠模型中的药代动力学-药效学建模及其抗锥虫活性
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2
Efficacy and safety assessment of different dosage of benznidazol for the treatment of Chagas disease in chronic phase in adults (MULTIBENZ study): study protocol for a multicenter randomized Phase II non-inferiority clinical trial.不同剂量苄硝唑治疗成人慢性期恰加斯病的疗效和安全性评估（MULTIBENZ 研究）：一项多中心随机、二期非劣效性临床试验方案。
Trials. 2020 Apr 15;21(1):328. doi: 10.1186/s13063-020-4226-2.
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Vismione B Interferes with Infection of Vero Cells and Human Stem Cell-Derived Cardiomyocytes.
Vismione B 干扰 Vero 细胞和人干细胞来源心肌细胞的感染。
Am J Trop Med Hyg. 2019 Dec;101(6):1359-1368. doi: 10.4269/ajtmh.19-0350.
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A Combination of Itraconazole and Amiodarone Is Highly Effective against Infection of Human Stem Cell-Derived Cardiomyocytes.伊曲康唑和胺碘酮联合治疗对人干细胞源性心肌细胞感染具有高度疗效。
Am J Trop Med Hyg. 2019 Aug;101(2):383-391. doi: 10.4269/ajtmh.19-0023.
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Pharmacokinetics of Benznidazole in Healthy Volunteers and Implications in Future Clinical Trials.健康志愿者中苯硝唑的药代动力学及其对未来临床试验的启示
Antimicrob Agents Chemother. 2017 Mar 24;61(4). doi: 10.1128/AAC.01912-16. Print 2017 Apr.
6
Lack of Clinical Pharmacokinetic Studies to Optimize the Treatment of Neglected Tropical Diseases: A Systematic Review.缺乏优化被忽视热带病治疗的临床药代动力学研究：一项系统评价。
Clin Pharmacokinet. 2017 Jun;56(6):583-606. doi: 10.1007/s40262-016-0467-3.
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Systematic Review and Meta-analysis of the Pharmacokinetics of Benznidazole in the Treatment of Chagas Disease.苯硝唑治疗恰加斯病药代动力学的系统评价与荟萃分析
Antimicrob Agents Chemother. 2016 Nov 21;60(12):7035-7042. doi: 10.1128/AAC.01567-16. Print 2016 Dec.
8
Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease.在恰加斯病小鼠模型中，用苯硝唑进行抗锥虫治疗优于泊沙康唑治疗方案。
Antimicrob Agents Chemother. 2015 Oct;59(10):6385-94. doi: 10.1128/AAC.00689-15. Epub 2015 Aug 3.
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Identification of N-benzylacetamide as a major component of human plasmatic metabolic profiling of benznidazole.鉴定N-苄基乙酰胺为苄硝唑人体血浆代谢谱的主要成分。
Eur J Drug Metab Pharmacokinet. 2015 Jun;40(2):209-17. doi: 10.1007/s13318-014-0195-8. Epub 2014 Apr 8.
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Pediatric clinical pharmacology studies in Chagas disease: focus on Argentina.恰加斯病的儿科临床药理学研究：聚焦阿根廷
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