Smith J E, Moore K, Board P G
Enzyme. 1980;25(4):236-40. doi: 10.1159/000459258.
Glutathione is synthesized from gamma-glutamylcysteine and glycine via the action of glutathione synthetase. It is known that gamma-glutamylcyclotransferase is present in many cells and may convert gamma-glutamylcysteine to 5-oxoproline and cysteine, but until now there has not been a credible explanation for the apparent suppression of the gamma-glutamylcyclotransferase reaction during glutathione synthesis. Our data suggest that the gamma-glutamylcyclotransferase and glutathione synthetase pathways are regulated by a simple kinetic mechanism that favors the synthesis of glutathione.
谷胱甘肽是由γ-谷氨酰半胱氨酸和甘氨酸通过谷胱甘肽合成酶的作用合成的。已知γ-谷氨酰环化转移酶存在于许多细胞中，可将γ-谷氨酰半胱氨酸转化为5-氧代脯氨酸和半胱氨酸，但迄今为止，对于谷胱甘肽合成过程中γ-谷氨酰环化转移酶反应的明显抑制，尚无可信的解释。我们的数据表明，γ-谷氨酰环化转移酶和谷胱甘肽合成酶途径受一种有利于谷胱甘肽合成的简单动力学机制调控。
